In vivo and in vitro efficacy of crocin against Echinococcus multilocularis

Parasites & Vectors

Table 1 Blood cell indexes and serum biochemical indexes of BALB/c mice after 6 weeks of crocin treatment (n = 6)

BALB/c mice	Control	Crocin50	Crocin100	F	P
ALT (U/L)	62.17 ± 5.71	62.17 ± 3.19	65.50 ± 4.93	0.9945	0.3930
AST (U/L)	189.80 ± 25.90	186.30 ± 2.62	185.00 ± 22.26	0.0668	0.9356
TBIL (μmol/L)	0.66 ± 0.21	0.60 ± 0.10	0.59 ± 0.16	0.2914	0.7513
DBIL (μmol/L)	0.09 ± 0.04	0.13 ± 0.05	0.13 ± 0.04	1.7910	0.2008
IBIL (μmol/L)	0.55 ± 0.18	0.53 ± 0.15	0.60 ± 0.21	0.2591	0.7752
TP (g/L)	61.93 ± 2.23	62.30 ± 3.30	61.22 ± 3.21	0.2090	0.8137
ALB (g/L)	28.02 ± 1.95	29.08 ± 2.03	28.58 ± 1.66	0.4805	0.6277
ALP (U/L)	84.50 ± 4.64	83.67 ± 6.15	86.33 ± 8.02	0.2710	0.7663
CRE (μmol/L)	15.80 ± 3.06	16.03 ± 1.94	16.00 ± 2.97	0.0131	0.9870
BUN (mmol/L)	9.24 ± 0.95	7.11 ± 1.81*	7.30 ± 0.55*	5.5770	0.0155
White blood cells (× 10⁹/L)	8.14 ± 1.40	8.10 ± 0.99	8.08 ± 1.22	0.0040	0.9962
Haemoglobin (g/L)	129.30 ± 8.07	128.80 ± 9.50	129.30 ± 11.98	0.0050	0.9950
Platelets (× 10⁹/L)	466.20 ± 45.31	481.80 ± 64.36	466.80 ± 63.64	0.1379	0.8723

Crocin50 Crocin administered at 50 mg/kg, Crocin100 crocin administered at 100 mg/kg, ALT alanine aminotransferase, AST aspartate aminotransferase, TBIL total bilirubin, DBIL direct bilirubin, IBIL indirect bilirubin, TP total protein,ALB albumin, ALP alkaline phosphatase, CRE creatinine, BUN blood urea nitrogen
* P < 0.05 versus control

ISSN: 1756-3305